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(A) Representative horizontal PET images of [18F]FESCH uptake (average 10–30 min) in the brain of healthy CD-1 mice under vehicle (15 min pre-injection of DMSO:Kolliphor® EL:0.9% NaCl, 1:2:7, 5 µL/g) and blocking conditions (15 min pre-injection of tozadenant 2.5 mg/kg in DMSO:Kolliphor® EL:0.9% NaCl, 1:2:7, 5 µL/g; red = striatum; yellow = cerebellum). (B) Averaged TACs of [18F]FESCH for vehicle (n = 4) and tozadenant pre-injected mice (n = 4) with SUVRs for striatum over cerebellum.
