Table 2.
Laboratory parameters of four studies
| Laboratory parameters (normal range) | Huang’s study [11] | Wang’s study [45] | Zhang’s study [46] | Guan’s study [4] | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| All (n = 41) | ICU (n = 13) | No ICU (n = 28) | All (n = 138) | ICU (n = 36) | No ICU (n = 102) | All (n = 138) | Severe (n = 56) | Non-severe (n = 82) | All (n = 1099) | Severe (n = 173) | Non-severe (n = 926) | |
| White blood cell count, × 109/L (4–10) | 6.2 (4.1–10.5) | 11.3 (5.8–12.1) | 5.7 (3.1–7.6) | 4.5 (3.3–6.2) | 6.6 (3.6–9.8) | 4.3 (3.3–5.4) | 4.7 (3.7–6.7) | 5.3 (4.0–9) | 4.5 (3.5–5.9) | 4.7 (3.5–6) | 3.7 (3–6.2) | 4.9 (3–6) |
| < 4 (no./total no., %) | 10/40 (25) | 1/13 (8) | 9/27 (33) | NA | NA | NA | 27/138 (19.6) | 9/56 (16.1) | 18/82 (22) | 330/978 (33.7) | 102/167 (61.1) | 228/811 (28.1) |
| > 10 (no./total no., %) | 12/40 (30) | 7/13 (54) | 5/27 (19) | NA | NA | NA | 17/138 (12.3) | 13/56 (23.2) | 4/82 (4.9) | 58/978 (5.9) | 39/811 (4.8) | 19/167 (11.4) |
| Neutrophil count, × 109/L (1.8–6.3) | 5.0 (3.3–8.9) | 10.6 (5.0–11.8) | 4.4 (2–6.1) | 3.0 (2–4.9) | 4.6 (2.6–7.9) | 2.7 (1.9–3.9) | NA | NA | NA | NA | NA | NA |
| Lymphocyte count, × 109/L (1.0–3.2) | 0.8 (0.6–1.1) | 0.4 (0.2–0.8) | 1 (0.7–1.1) | 0.8 (0.6–1.1) | 0.8 (0.5–0.9) | 0.9 (0.6–1.2) | 0.8 (0.6–1.1) | 0.7 (0.5–1.0) | 0.8 (0.6–1.2) | 1 (0.7–1.3) | 0.8 (0.6–1) | 1 (0.8–1.4) |
| < 1·0 (no./total no., %) | 26/41 (63) | 11/13 (85) | 15/28 (54) | NA | NA | NA | 104/138 (75.4) | 46/56 (82.1) | 58/82 (70.7) | NA | NA | NA |
| Prothrombin time (s) (9.4–12.5) | 11.1 (10.1–12.4) | 12.2 (11.2–13.4) | 10.7 (9.8–12.1) | 13 (12.3–13.7) | 13.2 (12.3–14.5) | 12.9 (12.3–13.4) | NA | NA | NA | NA | NA | NA |
| D-dimer (mg/L) (0–0.5) | 0.5 (0.3–1.3) | 2.4 (0.6–14.4) | 0.5 (0.3–0.8) | 203 (121–403) | 414 (191–1324) | 166 (101–285) | 0.2 (0.1–0.5) | 0.4 (0.2–2.4) | 0.2 (0.1–0.5) | NA | NA | NA |
| Albumin (g/L) (30–50) | 31.4 (28.9–36.0) | 27.9 (26.3–30.9) | 34.7 (30.2–36.5) | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Alanine aminotransferase (U/L) (9–50) | 32 (21–50) | 49 (29–115) | 27 (19.5–40) | 24 (16–40) | 35 (19–57) | 2 (15–36) | NA | NA | NA | NA | NA | NA |
| Aspartate aminotransferase (U/L) (15–40) | 34 (26–48) | 44 (30–70) | 34 (24–40.5) | 31 (24–51) | 52 (30–70) | 29 (21–38) | NA | NA | NA | NA | NA | NA |
| ≤ 40 (no./total no., %) | 26/41 (63) | 5/13 (38) | 21/28 (75) | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Total bilirubin (mmol/L) (5–21) | 11.7 (9.5–13.9) | 14 (11.9–32.9) | 10.8 (9.4–12.3) | 9.8 (8.4–14.1) | 11.5 (9.6–18.6) | 9.3 (8.2–12.8) | NA | NA | NA | NA | NA | NA |
| Lactate dehydrogenase (U/L) (25–245) | 286 (242–408) | 400 (323–578) | 281 (233–357) | 261 (182–403) | 435 (302–596) | 212 (171–291) | NA | NA | NA | NA | NA | NA |
| ≤ 245 (no./total no., %) | 11/40 (28) | 1/13 (8) | 10/27 (37) | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Hypersensitive troponin I (ng/mL) (< 28) | 3.4 (1.1–9.1) | 3.3 (3–163) | 3.5 (0.7–5.4) | 6.4 (2.8–18.5) | 11 (5.6–26.4) | 5.1 (2.1–9.8) | NA | NA | NA | NA | NA | NA |
| > 28 (no./total no., %) | 5/41 (12) | 4/13 (31) | 1/28 (4) | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Creatine kinase–MB (U/L) (< 25) | NA | NA | NA | 14 (10–18) | 18 (12–35) | 13 (10–14) | 72.5 (52.2–115) | 66 (38.5–144) | 83 (56.0–112) | NA | NA | NA |
| Procalcitonin (ng/mL) (< 0.05) | 0.1 (0.1–0.1) | 0.1 (0.1–0.4) | 0.1 (0.1–0.1) | NA | NA | NA | 0.07 (0.04–0.1) | 0.1 (0.06–0.3) | 0.05 (0.03–0.1) | NA | NA | NA |
| ≥ 0·5 (no./total no., %) | 3/39 (8) | 3/12 (25) | 0/27 | 49 (35.5) | 27 (75) | 22 (21.6) | 41/118 (34.7) | 25/50 (50) | 16/68 (23.5) | 35/633 (5.5) | 16/117 (13.7) | 19/516 (3.7) |
| < 0·1 (no./total no., %) | 27/39 (69) | 6/12 (50) | 21/27 (78) | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| C-reaction protein (mg/L) (0–3) | NA | NA | NA | NA | NA | NA | 34.2 (12.5–67.4) | 47.6 (20.6–87.1) | 28.7 (9.5–52.1) | NA | NA | NA |
ICU intensive care unit, NA not available