Figure 1.

Schematic illustration of the novel peripheral simulating bioreactor system. (A) Two servos (a and b) provide axial deformation and twisting, respectively. Servo (a) moves the harvested arteries (c) forward and backward in a linear motion. Servo b rotates the artery by degrees. The three-way values (d and e) are used to introduce flow and pressure to the artery. The artery is surrounded by matrigel, mimicking external tissue, providing support during vascular movement (insert, black arrow). (B,C) Harvested arteries under pulsatile (no deformation) and pulsatile conditions with peripheral deformation. (D,E) Gross photos of an uncoated balloon and a keratose–paclitaxel coated balloon. (F,G) Diameter measurements performed by ultrasound on the harvested artery.