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. 2020 Apr 3;25(7):1659. doi: 10.3390/molecules25071659

Figure 6.

Figure 6

Cross-sections of paired helical and straight tau filament core structures from Alzheimer’s disease. Cryo-EM density and atomic models of paired helical (A) and straight (B) tau filaments. Sharpened, high-resolution maps are shown in blue (paired helical filaments) and green (straight filaments). Paired helical and straight filaments are ultrastructural polymorphs. Their protofilament corresponds to residues V306-F378 of tau (R3 + R4 + 10 amino acids carboxy-terminal to the repeats). Unsharpened densities are shown in orange and grey. From [185]. Reprinted with permission from the publisher (John Wiley & Sons, Inc.).