Figure 6.

DMF prevents the formation and rupture of IAs in a mouse model without affecting blood pressure. (a) The percentage of aneurysms that formed and/or ruptured in mice treated with either DMF or a vehicle control. Fisher Exact Test was performed (*p < 0.05). (b) Mean arterial blood pressure was measured in DMF- and vehicle-treated mice and compared to sham-operated controls. ANOVA followed by Tukey post hoc analysis was performed (*p < 0.05). (c) Representative mouse brains demonstrating (i) No aneurysm formation, (ii) Aneurysm formation with no rupture, and (iii) Aneurysmal rupture with SAH.