Table 1.
Superimposition of C-alpha carbon atoms of the crystal structure of CYP3A4.
| 1TQN 1 | 1W0E 1 | 1W0F 2,3 | 1W0G 2 | 2V0M 2 | 3NXU 2 | |
|---|---|---|---|---|---|---|
| 1TQN | - | 7.23 | 7.25 | 7.40 | 6.16 | 4.58 |
| 1W0E | 7.23 | - | 1.66 | 2.10 | 10.54 | 8.65 |
| 1W0F | 7.25 | 1.66 | - | 1.58 | 10.59 | 8.72 |
| 1W0G | 7.40 | 2.10 | 1.58 | - | 10.67 | 8.83 |
| 2V0M | 6.16 | 10.54 | 10.59 | 10.67 | - | 4.19 |
| 3NXU | 4.58 | 8.65 | 8.72 | 8.83 | 4.19 | - |
1. Native (ligand unbound) Crystal Structures. PDB ids 1TQN and 1W0E. 2. Ligand bound Crystal Structures: PDB ids 1W0F (Progesterone), 1W0G (Metyrapone), 2V0M (Ketoconazole), and 3NXU (Ritonavir). 3. PDB Id 1W0F: Progesterone bound at a peripheral site, 17 Å away from heme.