Fig. 2.

Romidepsin causes increased growth delay in irradiated bladder cancer cell xenografts and prolongs mouse survival. (A) Weight changes in 7-week-old CD1-nude mice after 2 (left panel) or 3 (right panel) intraperitoneal injections of 1 mg/kg (n = 2), 2 mg/kg (n = 2), or 4 mg/kg (n = 2). (B) RT112 tumor xenograft growth after treatment with vehicle, ionizing radiation (6 Gy, single dose), romidepsin (4 mg/kg, single injection), or romidepsin + ionizing radiation (n = 6 in each group). (C) Time to quadruple tumor volume after indicated treatments. D) Kaplan-Meier survival curve showing plots of time to quadruple tumor volume after indicated treatments. All error bars represent ± standard error of the mean. ***P < .001; ****P < .0001.