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Scheme of polyethyleneimine (PEI)–siRNA polyplex hydrogels allowing localized long-term gene delivery. PPz-conjugated PEI and siRNA polyplex formed via ionic interaction undergo sol–gel transformation at body temperature in the target tissue. The dissolution and degradation of the hydrogels release the polyplex in a time-dependent manner, achieving long-term therapy gene silencing. Reprinted with permission from [72]. Copyright (2012) American Chemical Society.
