Table 1.
Top 50 downregulated genes in etv2ci32Gt homozygous embryos compared to etv2ci32Gt heterozygous embryos at the 15-somite stage and their reported expression patterns.
| Gene Symbol | Fold change | p | Expression pattern |
|---|---|---|---|
| gpr182 | −82.52 | 4.95E-04 | endothelial |
| mrc1a | −62.69 | 1.36E-03 | endothelial |
| agtr2 | −62.49 | 2.23E-05 | endothelial |
| ncf1 | −47.43 | 5.26E-06 | macrophage, neutrophil |
| mmp13a | −40.14 | 2.13E-04 | macrophage |
| flt1 | −37.79 | 2.36E-03 | endothelial |
| zgc:66382 | −34.46 | 4.76E-03 | exocrine pancreas |
| CABZ01018247.1 (pecam1) | −27.82 | 2.65E-06 | endothelial |
| cdh5 | −27.12 | 2.20E-03 | endothelial |
| clec14a | −26.57 | 1.87E-05 | endothelial |
| scarf1 | −21.96 | 1.49E-05 | endothelial |
| tie1 | −21.80 | 5.42E-05 | endothelial |
| si:zfos-1697h8.1 | −19.97 | 8.50E-05 | unknown |
| RASIP1 | −18.60 | 2.94E-05 | endothelial |
| CD93 | −17.85 | 2.91E-04 | endothelial |
| sla1a | −14.36 | 1.12E-03 | macrophage |
| myct1a | −13.88 | 1.33E-02 | endothelial |
| shank3b | −13.41 | 1.67E-04 | brain |
| cldn5b | −12.99 | 6.83E-04 | endothelial |
| INPP5D | −11.35 | 9.24E-03 | neutrophil |
| sox7 | −9.97 | 2.45E-05 | endothelial |
| erg | −9.92 | 1.13E-04 | endothelial |
| zgc:171534 | −9.82 | 1.39E-02 | unknown |
| si:dkey-80c24.1 | −9.63 | 1.87E-03 | unknown |
| samsn1a | −9.48 | 7.95E-03 | blood, macrophage |
| epdl2 | −9.02 | 3.64E-02 | unknown |
| dusp5 | −8.63 | 4.65E-04 | endothelial |
| tagap | −8.57 | 2.64E-02 | endothelial |
| KLHL4 | −8.49 | 1.28E-02 | endothelial |
| pde6c | −8.47 | 1.96E-02 | retina |
| PTPN6 | −7.90 | 5.62E-03 | macrophage |
| timd4 | −7.54 | 1.01E-02 | unknown |
| sod3a | −7.46 | 3.96E-03 | ubiquitous |
| CABZ01086927.1 | −7.36 | 5.41E-04 | unknown |
| kdr | −7.18 | 1.56E-03 | endothelial |
| etv2 | −7.09 | 5.65E-06 | endothelial |
| ARHGEF9 (1 of 3) | −7.09 | 2.15E-02 | endothelial |
| comtd1 | −6.85 | 1.08E-02 | liver, oligodendrocyte |
| CABZ01007930.1 (cldn34a) | −6.85 | 4.85E-02 | unknown |
| sele | −6.84 | 6.76E-04 | endothelial |
| GOLT1A | −6.63 | 1.49E-02 | unknown |
| si:ch73–248e21.5 | −6.56 | 4.29E-02 | unknown |
| arhgef9b | −6.16 | 2.25E-04 | endothelial |
| plbd1 | −6.15 | 2.37E-03 | yolk syncytial layer |
| si:dkey-241l7.2 (REG4) | −5.99 | 4.01E-02 | unknown |
| akr1a1a | −5.91 | 4.86E-03 | ubiquitous |
| ITGB2 | −5.79 | 8.11E-03 | unknown |
| pcxb | −5.79 | 4.43E-03 | ubiquitous |
| aqp8a.1 | −5.66 | 1.00E-04 | endothelial |
| cxcr3.2 | −5.51 | 2.69E-03 | macrophage |