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. Author manuscript; available in PMC: 2020 Apr 24.
Published in final edited form as: Cell Physiol Biochem. 2018 Sep 27;49(6):2293–2303. doi: 10.1159/000493831

Table 1:

Summary of biological activities of inosine mediated via adenosine receptors

AR subtype Target tissue Biological effect Reference
A1, A2A Hind paw (rat, mouse) Anti-nociception [65, 69]
A1, A2A Embryonic neocortex (rat) Neurite outgrowth [72]
A1, A2A Central nervous system (mouse) Anti-depression [70]
A2A Lumbar spinal cord (mice) Anti-nociception, Anti-inflammatory [35]
A2A, A2B Bladder (rat) Decreased spontaneous activity [24]
A2A, A3 Lung (mice) Anti-inflammatory [71]
A3 Mast cells Degranulation [68]