Figure 6.

Effect of bicyclol on hepatic AMPK, mTOR, and MAPK protein expressions at 24 and 48 h after CCl₄ exposure. Mice were intraperitoneally injected a mixture of CCl₄ (50%) and oil (50%) at a dose of 2 ml/kg body weight. Mice were given bicyclol 200 mg/kg by gavage for three times in 1 day 1 h prior to CCl₄ challenge. Results are presented as mean ± SD for five mice per group. Significantly different (^$$p < 0.01, ^$$$p < 0.001) from the CCl₄ 24 h group. Significantly different (^&p < 0.05, ^&&p < 0.01) from the CCl₄ 48 h group.