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. 2020 Apr 24;17:131. doi: 10.1186/s12974-020-01816-2

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Boc2 treatment of APP/PS1 double-transgenic mice improves spatial memory performance, analyzed by Morris water maze test. The eight-week-old APP/PS1 double-transgenic was injected for a period of 20 weeks with Boc2, fMLF, or Ac2-26. a mean distance to platform (m), (b) corrected integrated path length (m/s), (c) latency (s) time, and (d) path efficiency during the test trials were analyzed. (e) Representative track plot (test trial) of wildtype or APP/PS1 double-transgenic mice without or with Boc2 treatment. APP/PS1 double-transgenic mice showed a significantly worth performance in long-term memory compared to age-matched WT littermates. Boc2 treatment rescued this effect. The entry of the maze was top left and the platform position (small circle) bottom right. Statistical significances were determined using two-way ANOVAs followed by turkey post hoc test. Data represent mean + SEM; n ≥ 14; *p < 0.05, **p < 0.01