Fig. 1.

Schematic representation of study protocol for cohort 1. Male WT and ST2^−/− pups from ST2^+/− parents were placed at weaning in cages with other mice of the same genotype (same housed) or with mice of the opposite genotype (cohoused). Cages from each genotype/housing combination were assigned to either chow or high fat diet (HFD). After 12–13 weeks on the diet, mice were exposed to ozone (2 ppm) or air for 3 h. 24 h later, mice were anesthetized for the measurement of airway hyperresponsiveness (AHR). A bronchoalveolar lavage (BAL) was performed and blood was collected