Fig. 6.
Effect of HFD and ST2 deficiency on O3-induced airway hyperresponsiveness. Shown are changes in pulmonary resistance (RL) induced by inhaled aerosolized methacholine in WT and ST2−/− mice exposed to (a) air or (b) O3 (2 ppm for 3 h) and examined 24 h after exposure. All mice were same housed, as outlined in Fig. 1. Results are mean + SE of 6–11 mice/group. * p < 0.05 versus air exposed mice of same genotype and diet; # p < 0.05 versus chow fed mice with same genotype and exposure; % p < 0.05 versus WT mice with same exposure and diet