Fig. 3.

Mean plasma BC 007 concentration–time profiles of Part B, bolus with infusion (inf): solid curve; infusion only: dotted curve; in subjects who received the infusion with a bolus component, 50% of the total dose was delivered as a bolus and the remainder infused over 20 min; infusion was delivered over 20 min. a Cohort 1 (50 mg BC 007, 6 elderly males and females _fGPCR-AAb-positive), b Cohort 2 (150 mg BC 007, 6 elderly males and females _fGPCR-AAb positive). Error bars indicate the standard deviation. LOQ limit of quantification (5 ng/mL), _fGPCR-AAb functionally active agonistic autoantibodies against G-protein-coupled receptors