Fig. 4.

Mean plasma BC 007 concentration–time profiles of Part C, bolus with infusion (inf): solid curve; infusion only: dotted curve, in subjects who received the infusion with a bolus component, 150 mg BC 007 was delivered as a bolus and the remainder infused over 40 min. All cohorts comprised six elderly male and female _fGPCR-AAb-positive participants. a Cohort 1 (300 mg BC 007 in total, bolus 150 mg, infusion time 40 min), b Cohort 2 (450 mg BC 007 in total, bolus 150 mg, infusion time 40 min). c Cohort 3 (750 mg BC 007 in total, bolus 150 mg, infusion time 40 min). d Cohort 4 (1350 mg BC 007 infusion only, infusion time 75 min). e Cohort 5 (1900 mg BC 007 infusion only, infusion time 105 min). Error bars indicate the standard deviation. LOQ limit of quantification (5 ng/mL), _fGPCR AAb functionally active agonistic autoantibodies against G-protein-coupled receptors