Table 2.
Comparison of histopathological features in MOGAD autopsy and biopsy cohort
| Pathological feature | Present in autopsy (±) | Present in biopsies (±) | Frequency in Biopsy Cohort (%) |
|---|---|---|---|
| Plaque location | |||
| White matter | + | + | 14/20 (70%) |
| Cortex | + | + | 10/13 (77%) |
| Deep Gray Matter | + | + | 1/1 (100%) |
| White matter demyelination pattern | |||
| Perivenous | + | + | 3/14 (21%) |
| Confluent | + | + | 4/14 (29%) |
| Transitional (perivenous + confluent) | + | + | 7/14 (50%) |
| White matter plaque type | |||
| Chronic active with sharp macrophage border | – | – | 0/20 (0%) |
| Slowly expanding/smoldering | – | – | 0/20 (0%) |
| Cortical plaque type | |||
| Leukocortical | + | + | 1/13 (8%) |
| Intracortical | + | + | 9/13 (69%) |
| Subpial | + | + | 8/13 (62%) |
| Inflammatory features | |||
| Lymphocytes | + | + | 20/22 (91%) |
| Granulocytes | + | + | 17/22 (77%) |
| Meningeal Inflammation | + | + | 6/7 (86%) |
| Complement Deposition (Pattern II) | + | + | 8/8 (100%) |
| Complement deposition glial limitans | – | – | 0/8 (0%) |
| Comparative Myelin Immunohistochemistry | |||
| MAG loss > MOG loss (pattern III) | – | + | 1/8 (13%) |
| MOG loss > MAG loss | – | – | 0/20 (0%) |
| Cellular features | |||
| Oligodendrocyte apoptosis | + | + | 9/20 (45%) |
| Axonal spheroids | + | + | 7/13 (54%) |
| Axonal loss | + | + | 1/13 (8%) |
| Astrogliosis | + | + | 21/22 (95%) |
| Creutzfeldt-Peters cell | + | + | 3/22 (14%) |
| Dystrophic astrocytes | – | – | 0/22(0%) |
| AQP4 loss | – | – | 0/17 (0%) |
Variable denominators are based on number of biopsies containing specific region analyzed for a given feature (i.e., white matter, cortex), available staining, or feature classification based on specific stage of demyelinating activity (i.e., immunopattern)