. 2020 Apr 23;10:6894. doi: 10.1038/s41598-020-63749-3

Table 2.

Histological features of renal biopsies at D0, D15-D30, M3 and M12.

	D0 (n = 43)	D15-D30 (n = 20)	M3 (n = 28)	M12 (n = 28)	p value
Acute lesions:
Glomerulitis « g »	0 ± 0	0.2 ± 0.4	0.08 ± 0.3	0.07 ± 0.3	0.12
Peritubular capillaritis « ptc »	0 ± 0	0.1 ± 0.3	0.08 ± 0.3	0.04 ± 0.2	0.41
Interstitial inflammation « i »	0 ± 0	0.2 ± 0.7	0.3 ± 0.5	0.07 ± 0.3	0.01
Total inflammation « ti »	0.1 ± 0.3	0.2 ± 0.7	0.6 ± 0.8	0.8 ± 0.8	<0.001
Tubulitis « t »	0 ± 0	0.2 ± 0.7	0.2 ± 0.4	0.1 ± 0.4	0.03
Intimal arteritis « v »	0 ± 0	0 ± 0	0.04 ± 0.2	0.04 ± 0.2	0.54
Acute tubular injury (%)	63 ± 28	47 ± 22	9 ± 11	4 ± 6	<0.05
Chronic lesions:
Sclerotic glomeruli	3.5 ± 5.1	2.0 ± 3.5	4.4 ± 6.7	9.0 ± 14.0	0.11
Allograft glomerulopathy « cg »	0 ± 0	0 ± 0	0 ± 0	0.04 ± 0.2	0.37
Mesangial matrix increase « mm »	0 ± 0	0 ± 0	0.1 ± 0.3	0.2 ± 0.5	0.01
Interstitial fibrosis « ci »	0.6 ± 0.5	0.7 ± 0.6	1.5 ± 0.8	1.7 ± 0.9	<0.001
Tubular atrophy « ct »	0.2 ± 0.5	0.4 ± 0.5	1.2 ± 0.8	1.5 ± 0.9	<0.001
Vascular fibrous intimal thickening « cv »	0.3 ± 0.5	0.8 ± 0.9	1.0 ± 1.1	0.7 ± 0.9	<0.01
Arteriolar hyaline thickening « ah »	0.3 ± 0.5	0.2 ± 0.4	0.4 ± 0.6	0.4 ± 0.6	0.49
C4d (immunofluorescence):
Negative (0 or minimal 1)	37/37(100%)^a	15/17(88%)^b	24/25(96%)^b	25/26(96%)^c	0.22
Positive (focal 2 or diffuse 3)	0/37(0%)^a	2/17(12%)^b	1/25(4%)^b	1/26(4%)^c	0.22
Rejection:
Antibody-mediated rejection (n)	NA	2^d	1^e	1^e
Borderline rejection (n)	NA	0	4	3
T-cell-mediated rejection (n)	NA	1 ^f	0	1 ^g
Other lesions:

Digital data are means ± standard deviation.

^aNA = 6.

^bNA = 3.

^cNA = 2.

^dAntibody-mediated rejection included: 1 acute antibody-mediated rejection, and 1 “suspicious” for acute antibody-mediated rejection.

^eacute antibody-mediated rejection.

^fgrade Ib.

^gchronic T-cell mediated rejection.