Table 4.

Spearman rank correlation coefficients (r) and p-values between FOXO1 and FOXO3 protein levels and other proteins of different pathways in the series of 218 breast tumours.

	FOXO1 protein		FOXO3 protein
	r	p-value	r	p-value
PI3K/AKT/mTOR pathway
Phospho-S6K (Thr-421/Ser-424)		NS	−0.252	0.0002
Phospho-S6K (Thr-389)		NS	−0.163	0.016
Phospho-S6 (Ser-235/236)		NS	−0.186	0.0058
Phospho-S6 (Ser-24)	+0.141	0.038	−0.301	<0.0001
AKT		NS	−0.317	<0.0001
PDK1	−0.186	0.0060	−0.181	0.0073
mTor		NS	−0.178	0.0086
S6 Rib		NS	−0.446	<0.0001
IRS1		NS	−0.172	0.011
PTEN		NS		NS
DNA repair
Ku80	−0.137	0.043	−0.327	<0.0001
DNA-PK		NS	−0.144	0.034
PARP		NS	−0.401	<0.0001
NBS1	−0.156	0.021	−0.303	<0.0001
RAD50		NS	−0.181	0.0072
Mre11	−0.137	0.043	−0.203	0.0026
Apoptosis
P53		NS	+ 0.299	<0.0001
Phospho-p53 (Ser-15)		NS	+ 0.320	<0.0001
Phospho-p53 (Ser-392)		NS	+ 0.387	<0.0001
Cell cycle
p15		NS	+ 0.392	<0.0001
Proliferation
KI67	+ 0.134	0.049	−0.46	<0.0001