Table 3.

Multivariare Cox regression models for MLR, NLR and NLR-MLR Score.

	HR	95% CI	P value
Matched population*
MLR
<0.28	1.00
≥0.28	1.85	1.20–2.83	0.004
NLR
<2	1.00
≥2	1.37	0.85–2.19	0.196
NLR-MLR Score
Score 0	1.00
Score 1	1.38	0.75–2.56	0.300
Score 2	1.90	1.11–3.26	0.19
Total population**
MLR
<0.28	1.00
≥0.28	1.37	0.99–1.89	0.053
NLR
<2	1.00
≥2	1.14	0.80–1.63	0.454
NLR-MLR Score
Score 0	1.00
Score 1	1.18	0.74–1.88	0.494
Score 2	1.38	0.92–2.08	0.123
HER2-positive and Triple Negative subgroups*
MLR
<0.28	1.00
≥0.28	1.92	1.15–3.22	0.013
NLR
<2	1.00
≥2	0.91	0.48–1.72	0.768
NLR-MLR Score
Score 0	1.00
Score 1	0.90	0.39–2.08	0.810
Score 2	1.46	0.74–2.89	0.274

^*Corrected for molecular profiles, ECOG PS, number of sites, CNS involvement at fist line.

**Corrected for molecular profiles, ECOG PS, number of sites, CNS and liver involvement at fist line.