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. 2020 Apr 24;10:7004. doi: 10.1038/s41598-020-64018-z

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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SM-164 inhibits the growth of metastatic MDA-MB-231 cancer cells in bone. (A) Scheme showing that MDA-MB-231^luci cells were inoculated into the left cardiac ventricle of 7-wk-old female athymic nude mice followed by treatment with vehicle, SM-164, standard chemotherapy (SCT) or BV6, starting on the 2^nd day. (B) Mice were monitored weekly by BLI. Representative BLI images and BLI signal intensity in hind limbs after 2 and 4 weeks of treatment are shown, 7-8 mice each group, in which BLI signal intensity of each leg was calculated individually. *p < 0.05 and **p < 0.01. One-way ANOVA +/Dunnett test. The horizontal line at 10⁵ indicates the mean value in the mice at baseline.