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. 2020 Apr 24;10:6956. doi: 10.1038/s41598-020-63255-6

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Aβo_1-42 exposure impacts cell viability and NLGN1 in primary neuronal culture. (A) Neuronal viability of hippocampal neurons exposed to 2 µM of Aβo_1-42 or vehicle (VH) for 48 and 72 hours. A significant Treatment-by-Time interaction was found (two-way ANOVA F_1,39 = 12.6, p = 0.001), with difference between Aβo_1-42 and VH restricted to 72 hours of treatment (stars indicating planned comparison, also in B). (B) NLGN1 protein level in primary culture of hippocampal neurons was assessed by Western blot (top) and expressed relative to the control protein GAPDH (bottom) after exposure to 2 µM of Aβo_1-42 or VH for 48 and 72 hours. A significant Treatment-by-Time interaction was also found (two-way ANOVA F_1,22 = 5.43, p = 0.03), with difference between Aβo_1-42 and VH also restricted to 72 hours of treatment. Full length blots are shown in Supplementary Fig. 4. The number of replicate is indicated on each bar.