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. 2020 Apr 24;11(4):272. doi: 10.1038/s41419-020-2457-5

Fig. 7. AKT-mTOR signaling is involved in FADS1-mediated action.

Fig. 7

The expression relationship between FADS1 and AKT1 (a), mTOR (b), S6K1 (c) in HSNC in published database from GEPIA. d AKT, p-AKT and its downstream targets (mTOR, S6K1) were evaluated by western blot in the indicated laryngeal cancer cells (NC, OE, Con, KD). e The representative figure of xenograft tumors of FADS1-OE group and FADS1-KD group (n = 6/group). The tumors formed by FADS1-OE cells were obviously larger compared with FADS1-NC cells while the tumors formed by FADS1-KD cells were remarkably smaller than by FADS1-Con cells. f The expression of FADS1, AKT, p-AKT, mTOR, p-mTOR, S6K1, and p-S6K1 in the xenograft tumors were examined by western blot. Each representative image was shown with quantitative analysis on the right side. g The expression of p-AKT and p-mTOR were examined by IHC staining in the xenograft tumor tissues. *P < 0.05, **P < 0.01, ***P < 0.001 by Student’s t-test. All data are represented as mean ± SEM.