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. 2020 Apr 24;3:193. doi: 10.1038/s42003-020-0933-1

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8 — a In vivo anti-tumor efficacy of KH-3 in MDA-MB-231 orthotopic xenograft model. KH-3 treatment significantly inhibits the tumor growth compared to the vehicle control (n = 12, **P < 0.01, ***P < 0.001, two-way ANOVA). b Protein expression levels of HuR and downstream targets in tumor tissues after treatment. α-Tubulin is used as loading control. c, d Kaplan–Meier analysis of the initiation of pulmonary metastases (c) and overall survival of mice (d) comparing treatment with vehicle control or KH-3 in an experimental metastasis model (n = 9, *P < 0.05, **P < 0.01, log-rank test). e Schematic of screening for HuR inhibitors that bind to HuR and block HuR function. f Proposed working model of KH-3 inhibiting breast cancer invasion and metastasis.