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. 2020 Apr 24;11:1972. doi: 10.1038/s41467-020-15879-5

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Structural superimposition of C-REV7 (green)–SHLD3 (magenta) and REV3-C-REV7-REV1 (PDB: 3VU7). The superimposition was done by align C-REV7. C-REV7 is shown in surface representation, REV1 and SHLD3 in ribbon view, and the FXPWFP motif in sticks. Residues Leu1203 and Tyr1244 of REV1 that contribute its interaction with REV7 are shown in sticks. b–g ITC measurements of interaction between cREV1 CTD and distinct REV7^K44A-SHLD3(1–82) truncations, mutants or REV7^WT-REV3(1871–2021). REV7^WT-REV3(1871–2021) is a representative C-REV7 that binds to cREV1 CTD. The calculated N and K_D are indicated as described in Fig. 2d. N.D.: no detectable binding. Source data are provided as a Source Data file.