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. 2020 Apr 24;11:1972. doi: 10.1038/s41467-020-15879-5

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a Details of the hydrogen bond network (the left panel) and hydrophobic network (the right panel). In the detailed view, αB of O-REV7 and side chains that do not contribute to polar contacts are omitted for convenience to read. b Hydrophobic network in the reverse side rotated along y-axis compared with Fig. 6a. c Structural alignment of C-REV7-RBM₂^S3 and O-REV7-SHLD2-SHLD3. The regions between two lines represent safety belt and are colored in orange (C-REV7) and slate (O-REV7). RBM₂^S3 represents RBM₂ of SHLD3 and is colored in salmon. The superscript S2 and S3 represents SHLD2 and SHLD3, respectively. d Molecular dynamics simulation results of the SHLD3-C-REV7-O-REV7 complex and structural alignment of SHLD3-REV7-SHLD2 complex and SHLD3-C-REV7-O-REV7 complex shows the interaction model of SHLD3 β1 and O-REV7. MD-SHLD3 and MD-REV7 shows structures of SHLD3 and O-REV7 after molecular dynamics simulation. The secondary structures of SHLD2 are labeled in detail.