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. 2019 Aug 13;12(3):216–229. doi: 10.1093/jmcb/mjz048

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© The Author(s) (2019). Published by Oxford University Press on behalf of Journal of Molecular Cell Biology, IBCB, SIBS, CAS.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Decreased ERG response and deteriorated photoreceptor in Hsp90α-deficient mice. (A) ERG was recorded for Hsp90α-deficient mice or their wild-type littermates at postnatal 3 and 20 weeks. The rod-ERG and max-ERG were recorded in order. (B) Statistical analysis of ERG amplitudes. The amplitudes of a-wave and b-wave of rod-ERG and max-ERG were analyzed. Data are mean ± SEM of the results obtained from 10 mice at the age of 3 weeks and 3 mice at 20 weeks for each group. Student’s t-test, *P < 0.05, **P < 0.01, ***P < 0.001. (C) SEM observation of deformed photoreceptors in 15-week Hsp90α-deficient mice. The black arrows point to the bulged OSs in Hsp90α-deficient mice. Scale bar, 2 μm. (D) TEM observation of OS discs in photoreceptors of 15-week Hsp90α-deficient mice. The boxed areas are enlarged to show details. Scale bar, 1 μm.