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. 2019 Sep 3;12(3):202–215. doi: 10.1093/jmcb/mjz090

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© The Author(s) (2019). Published by Oxford University Press on behalf of Journal of Molecular Cell Biology, IBCB, SIBS, CAS.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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CXCR1/2 inhibition prevented the M2 macrophage polarization induced by CA-MSCs. (A) The cytotoxic activity of the macrophages was evaluated as described Figure 5D and E in the presence of a CXCR1/2 inhibitor. (B) The ROS production by peritoneal macrophages isolated from mice injected with SKOV-3 cells admixed or not with MSCs and treated or not with carboplatin +/− CXCR1/2 inhibitor was analyzed. (C and D) Gene expression analysis of peritoneal macrophages was analyzed by RT-qPCR (8 mice/group) on M2 (IL-10, CCL17, dectin-1, and arginase-1) and M1 (IL-6, IL-1β, and TLR-2) markers. P-values of <0.05 (*) using a Wilcoxon–Mann–Whitney test indicate a significant difference.