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Roles of MSCs and macrophages on ovarian tumor. (A) Secreted factors by OTCs induce differentiation of MSC into CA-MSC, which in turn lead to the secretion of chemopreventive factors such as CXCL1/2 and IL-8. These chemokines polarize monocytes/macrophages to a M2 pro-tumoral phenotype promoting tumor growth. (B) CXCR1/2 inhibition restores carboplatin sensitivity in OTCs and reinstates the anti-tumoral activity of tumor-associated macrophages, thereby improving treatment efficiency.
