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. 2020 Apr 23;3:188. doi: 10.1038/s42003-020-0922-4

Fig. 1. Single-cell RNA sequencing analysis of sun-protected whole human skin identifies seventeen distinct cell populations.

Fig. 1

a Uniform manifold approximation and projection (UMAP) plot depicting single-cell transcriptomes from whole human skin (n = 5). Each dot represents a single cell (n = 15,457). Coloring is according to the unsupervised clustering performed by Seurat. b Heatmap showing the five most differentially expressed genes of each cell cluster, as provided by Seurat. Each column represents a single cell, each row represents an individual gene. Two marker genes per cluster are shown on the right. Yellow indicates maximum gene expression and purple indicates no expression in scaled log-normalized UMI counts. c Average expression of 3–5 well-established cell type markers was projected on the UMAP plot to identify all cell populations (see Methods for details). Red indicates maximum gene expression, while blue indicates low or no expression of a particular set of genes in log-normalized UMI counts. DC dendritic cells, EC endothelial cells.