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. 2020 Apr 24;10:6970. doi: 10.1038/s41598-020-63559-7

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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AAV2.retro-mediated delivery of mHTT into the rhesus macaque striatum leads to aggregate formation in many disease-relevant brain regions. (a) AAV2.retro vector cartoon and (b) surgical injection graphic depicting unilateral injection sites of AAV2.retro-HTT85Q into the caudate and putamen. 1-82aa staining of mHTT protein showing mHTT⁺ aggregates in the caudate (c), putamen (d) and several cortical and subcortical brain regions. Examples shown here include the AMY (e), THAL (f), DPFC (g), DPMC (h), ACC (i) and SSC (j). Double label immunofluorescence of HTT 1-82aa/NeuN (k–p) and HTT 1-82aa/GFAP (q–v) in the injection site (putamen, left panel) and a distal brain region (DMPC, right panel). Transduced neurons and astrocytes are indicated with chevrons. Abbreviations: ACC (anterior cingulate cortex), AMY (amygdala), Cd (caudate), DPFC (dorsal prefrontal cortex), DPMC (dorsal premotor cortex), Put (putamen), SSC (somatosensory cortex), THAL (thalamus). Scale bar in g = 100 microns, scale bar in q = 30 microns. Brain graphic in 4b was made using the 3d Brain Composer feature on the Scalable Brain Atlas website (https://scalablebrainatlas.incf.org/composer/?template=CBCetal15).