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. 2020 Apr 24;10:6970. doi: 10.1038/s41598-020-63559-7

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Schematic of the functional cortico-basal ganglia circuits targeted via intra-striatal delivery of AAV2.retro. Delivery of AAV2.retro into the caudate and putamen leads to transgene expression (both eGFP and mHTT85Q) in dozens of highly interconnected brain regions comprising cognitive, sensorimotor and limbic cortico basal ganglia functional neural networks. Schematic was created using Microsoft Powerpoint for Mac, version 16.35.