Fig. 3. Pedigree of carriers of Lys334Ter in ACO1.

All 67 carriers can be traced back to a common ancestor in the early 18th century. The founding couple had six offspring and a current total number of 21,423 descendants. Roman numerals indicate generation, year of birth of the founding couple is noted above the symbols and mean hemoglobin concentration is noted below the symbols. Square = male, circle = female, diamond = sex unspecified, solid filled object = carrier, half filled object = obligate carrier, red filled object = polycythemic.