Fig. 6. ApoJ → LRP2 signaling is required for insulin-stimulated glucose uptake.

a Insulin-stimulated glucose uptake in muscle, adipose tissue, and brown adipose tissue (BAT) was measured in control and L-ApoJ^−/− mice (muscle: n = 20 per group, adipose tissue: n = 16 per group, BAT: n = 20 for control, n = 19 for L-ApoJ^−/−). Mice were studied at 18 weeks of age. b Insulin-stimulated glucose uptake in muscle, adipose tissue, and BAT was measured in control M-LRP2^−/− mice (muscle: n = 10 for control, n = 8 for M-LRP2^−/−, adipose tissue: n = 10 for control, n = 7 for M-LRP2^−/−, BAT: n = 10 for control, n = 8 for M-LRP2^−/−). Mice were studied at 17 weeks of age. Mice were injected with insulin in combination with [¹⁴C]2-deoxyglucose. In vivo 2-deoxyglucose uptake was measured. All bars and errors represent means ± SEM. p values by two-sided Student’s t-test in a and b are indicated.