Figure 4.

Gonadotrope-specific Foxl2/Smad4 knockout mice carrying the hFSHB transgene are hypogonadal. Representative images of reproductive organs from (A) female and (B) male control (hFSHB/hFSHB;Foxl2^fx/fx;Smad4^fx/fx;Gnrhr^+/+) and deletion mutant (hFSHB/hFSHB;Foxl2^fx/fx; Smad4^fx/fx;Gnrhr^GRIC/+) mice. Ovarian (C) and testicular (D) histology in 7- to 8-week-old control and deletion mutant mice. Individual follicles from the 2 genotypes are shown at higher magnification at the right in (C). Ovarian (E), testicular (F), uterine (G), and seminal vesicle (H) weights (normalized by body weight) are plotted individually. Means are shown as horizontal lines. *P < 0.05, **P < 0.01, n.s., not statistically significant vs. control mice by unpaired t-test.