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. Author manuscript; available in PMC: 2020 Apr 24.
Published in final edited form as: Cancer Res. 2015 Aug 20;75(19):4188–4197. doi: 10.1158/0008-5472.CAN-15-0858

Figure 5.

Figure 5.

Aki1 and phosphorylated CREB are frequently expressed in DMM. Clinical specimens from DMM patients evaluated for Aki1 and phosphorylated CREB by immunohistochemistry. A, high cytoplasmic Aki1 protein expression was detected in 15 (22.1%), intermediate in 22 (32.4%), low in 28 (41.2%), and negative expression in 3 (4.4%) of 68 DMM tumors. High nuclear expression of phosphorylated CREB protein was detected in 16 (45.7%), intermediate in 12 (34.3%), low in 2 (5.7%), and negative expression in 5 (14.3%) of 35 DMM tumors. B, representative images of epithelioid DMM, hematoxylin and eosin stain (H&E), showing diffuse expression of calretinin, p-CREB, and Aki1. C, the correlation of expression scores between Aki1 and phosphorylated CREB in tumors of DMM patients (Spearman rank correlations = 0.521; P = 0.002, N = 34).