Table 404.1.
The clans and families of cysteine peptidases
| Clan CA | Catalytic residues: Gln, Cys, His, Asn (or Asp) | Fold: Helices+β-barrel |
| Family (or subfamily) |
C1A | papain (Carica papaya) |
| C1B | bleomycin hydrolase (Saccharomyces cerevisiae) | |
| C2A | calpain 2 (Homo sapiens) | |
| C2B | Tpr peptidase (Porphyromonas gingivalis) | |
| C10 | streptopain (Streptococcus pyogenes) | |
| C12 | ubiquitin C-terminal hydrolase UCH-L1 (Homo sapiens) | |
| C16A | murine hepatitis coronavirus papain-like endopeptidase 1 | |
| C16B | murine hepatitis coronavirus papain-like endopeptidase 2 | |
| C19 | ubiquitin-specific protease 14 (Homo sapiens) | |
| C28 | foot-and-mouth disease virus L-peptidase | |
| C31 | porcine respiratory and reproductive syndrome arterivirus-type cysteine peptidase alpha (lactate-dehydrogenase-elevating virus) | |
| C32 | equine arteritis virus-type cysteine peptidase (porcine reproductive and respiratory syndrome virus) | |
| C33 | equine arterivirus Nsp2 cysteine peptidase | |
| C39 | bacteriocin-processing peptidase (Pediococcus acidilactici) | |
| C47 | staphopain (Staphylococcus aureus) | |
| C51 | d-alanyl-glycyl endopeptidase (Staphylococcus aureus) | |
| C54 | Aut2 peptidase (Saccharomyces cerevisiae) | |
| C58A | YopT peptidase (Yersinia pestis) | |
| C58B | HopN1 peptidase (Pseudomonas syringae) | |
| C64 | Cezanne deubiquitinylating peptidase (Homo sapiens) | |
| C65 | otubain-1 (Homo sapiens) | |
| C66 | IdeS peptidase (Streptococcus pyogenes) | |
| C67 | CylD protein (Homo sapiens) | |
| C70 | AvrRpt2 peptidase (Pseudomonas syringae) | |
| C71 | pseudomurein endoisopeptidase Pei (Methanobacterium phage psiM2) | |
| C76 | UL36 deubiquitinylating peptidase (human herpesvirus 1) | |
| C78 | UfSP1 peptidase (Mus musculus) | |
| C83 | gamma-glutamylcysteine dipeptidyltranspeptidase (Nostoc sp. PCC 7120) | |
| C85 | DUBA deubiquitinylating enzyme (Homo sapiens) | |
| C86 | ataxin-3 (Homo sapiens) | |
| C87 | nairovirus deuquitinylating peptidase (Crimean-Congo hemorrhagic fever virus) | |
| C88 |
OTU1 peptidase (Saccharomyces cerevisiae) |
|
| Clan CD | Catalytic residues: His, Cys | Fold: β, α, β-sandwich |
| Family |
C11 | clostripain (Clostridium histolyticum) |
| C13 | legumain (Canavalia ensiformis) | |
| C14A | caspase-1 (Rattus norvegicus) | |
| C14B | metacaspase Yca1 (Saccharomyces cerevisiae) | |
| C25 | gingipain R (Porphyromonas gingivalis) | |
| C50 | separase (Saccharomyces cerevisiae) | |
| C80 | RTX self-cleaving toxin (Vibrio cholerae) | |
| C84 |
prtH peptidase (Bacteroides forsythus) |
|
| Clan CE | Catalytic residues: His, Asp (or Asn), Gln, Cys | Fold: β-barrel+helices |
| Family |
C5 | adenain (human adenovirus type 2) |
| C48 | Ulp1 endopeptidase (Saccharomyces cerevisiae) | |
| C55 | YopJ protease (Yersinia pseudotuberculosis) | |
| C57 | vaccinia virus I7 processing peptidase | |
| C63 | African swine fever virus processing peptidase (African swine fever virus) | |
| C79 |
ElaD peptidase (Escherichia coli) |
|
| Clan CF | Catalytic residues: Glu, His, Cys | Fold: α, β, α-sandwich |
| Family | C15 | pyroglutamyl peptidase I (Bacillus amyloliquefaciens) |
| Clan CL | ||
| Family |
C60A | sortase A (Staphylococcus aureus) |
| C60B | sortase B (Staphylococcus aureus) | |
| C82 |
l,d-transpeptidase (Enterococcus faecium) |
|
| Clan CM | ||
| Family | C18 | peptidase 2 (hepatitis C virus) |
| Clan CN | ||
| Family | C9 | nsP2 peptidase (Sindbis virus) |
| Clan CO | ||
| Family | C40 | dipeptidyl-peptidase VI (Bacillus sphaericus) |
| Subclan PA(C) | Catalytic residues: His, Cys | Fold: two β-barrels |
| Family (or subfamily) | C3A | poliovirus type 1 picornain 3C |
| C3B | poliovirus type 1 picornain 2A | |
| C3C | foot-and-mouth disease virus picornain 3C | |
| C3D | cowpea mosaic comovirus picornain 3C | |
| C3E | hepatitis A virus picornain 3C | |
| C3F | human parechovirus 1 picornain 3C | |
| C3G | rice tungro spherical virus endopeptidase | |
| C4 | nuclear-inclusion-a endopeptidase (plum pox potyvirus) | |
| C24 | rabbit hemorrhagic disease virus 3C endopeptidase | |
| C30 | murine hepatitis coronavirus picornain 3C-like endopeptidase | |
| C37 | Southampton virus processing peptidase | |
| C38 | parsnip yellow fleck virus putative processing peptidase | |
| C74 | pestivirus NS2 peptidase (bovine viral diarrhea virus 1) | |
| Clan PD(C) | Catalytic residues: Cys, Thr, His | Fold: all β |
| Family | C46 | hedgehog protein (Drosophila melanogaster) |
| Subclan PC(C) | Catalytic residues: Cys, His | Fold: α, β, α-sandwich |
| Family | C26 | γ-glutamyl hydrolase (Rattus norvegicus) |
| Family | C56 | PfpI endopeptidase (Pyrococcus furiosus) |
| Not assigned to clan | Catalytic residues: not applicable | Fold: not applicable |
| Family | C6 | potyvirus helper component endopeptidase (potato virus Y) |
| C7 | chestnut blight fungus virus p29 endopeptidase (Cryphonectria hypovirus) | |
| C8 | chestnut blight fungus virus p48 endopeptidase (Cryphonectria hypovirus) | |
| C21 | tymovirus endopeptidase (turnip yellow mosaic virus) | |
| C23 | carlavirus endopeptidase (apple stem pitting virus) | |
| C27 | rubella virus endopeptidase | |
| C36 | beet necrotic yellow vein furovirus papain-like endopeptidase | |
| C42 | beet yellows virus papain-like endopeptidase | |
| C53 | pestivirus Npro endopeptidase (classical swine fever virus) | |
| C75 | AgrB peptidase (Staphylococcus aureus) | |
For each family the identity of the MEROPS type example is given.