Orii 2000.

Methods	Randomised clinical trial.
Participants	Country: Japan. Number randomised: initially 45, post randomisation drop outs 0, final participants number 45. Mean age: 66 years. Females: 8 (17.8%). Cirrhotic livers: 45 (100%). Steatotic livers: not stated. Inclusion criteria: 1. Liver resection. 2. Bilirubin < 2 mg/dl. 3. Indocyanin green (ICG) elimination rate > 0.06 U/min. 4. Cirrhotics with hepatocellular carcinoma. 5. Tumour limited to one segment. 6. Pringle's manoeuvre used to induce liver ischaemia. Exclusion criteria: 1. Ascites. 2. ASA score III to V.
Interventions	Participants were randomly assigned to three groups: Intervention group 1: administered an intravenous infusion of amrinone at a rate of 4 mcg/kg/min through a central venous catheter. The infusion was initiated at the start and terminated at the end of surgery (n = 15). Intervention group 2: administered an intravenous infusion of PGE1 at a rate of 0.02 mcg/kg/min through a central venous catheter. The infusion was initiated at the start and terminated at the end of surgery (n = 15).
Outcomes	The outcomes reported were mortality, blood loss, and enzyme markers of liver injury.
Notes	We contacted the authors for information regarding random sequence generation and allocation concealment (questions sent January 2008). There was no reply from the authors.
Risk of bias
Bias	Authors' judgement	Support for judgement
Blinding? All outcomes	High risk	Comment: not a double blind trial.
Incomplete outcome data addressed? outcomes 2‐4 weeks	Low risk	Comment: no post randomisation drop‐outs.
Free of selective reporting?	High risk	Comment: not all important outcomes reported.
Free from academic bias?	Low risk	Comment: no previous published studies of the same comparison by the trial authors.
Free from source of funding bias?	Low risk	Quote: "This work was supported in part by a Grand‐in‐aid for Scientific Research from the Ministry of Education, Science and Culture of Japan".