Table 1.

Genetic Loci with Significant Natural Selection Signatures in the Japanese Population Detected by ASMC.

Chr	Position (Mb)	Cytoband	P ASMC	Gene(s)
1	35.635–36.412	1p34	2.0 × 10−8	PSMB2
1	75.623–76.469	1p31	1.3 × 10−8	SLC44A5
1	193.833–193.994	1q31	4.1 × 10−7	CDC73
2	8.983–9.798	2p25	9.7 × 10−11	ASAP2
2	17.139–17.791	2p24	2.0 × 10−8	RAD51AP2
2	38.239–38.623	2p22	8.8 × 10−10	CYP1B1
2	108.430–109.524	2q12	6.0 × 10−10	EDAR
2	125.760–126.395	2q14	3.5 × 10−7	CNTNAP5
2	158.772–158.880	2q24	4.3 × 10−7	UPP2
2	211.547–211.903	2q34	5.1 × 10−9	CPS1
2	213.033–213.295	2q34	4.2 × 10−8	ERBB4
3	134.389–134.622	3q22	6.3 × 10−8	EPHB1
4	28.250–28.870	4p15	5.6 × 10−9	MIR4275
4	99.528–100.979	4q23	2.2 × 10−36	The ADH cluster
4	122.149–122.362	4q27	2.5 × 10−7	QRFPR
4	158.116–159.173	4q32	4.1 × 10−11	GRIA2
6	18.713–19.444	6p22	1.1 × 10−9	MIR548A1
6	29.736–30.075	6p21	7.2 × 10−8	The MHC region
7	112.095–112.500	7q31	9.5 × 10−8	LSMEM1
8	139.643–139.676	8q24	4.9 × 10−7	COL22A1
9	0.204–0.399	9p24	6.4 × 10−10	DOCK8
10	94.357–95.174	10q23	6.2 × 10−13	MYOF
11	24.896–25.467	11p14	3.6 × 10−8	LUZP2
12	1.207–1.549	12p13	1.9 × 10−7	ERC1
12	111.746–113.238	12q24	7.0 × 10−8	ALDH2
13	63.401–64.618	13q21	1.1 × 10−11	—
13	74.493–74.862	13q22	2.2 × 10−8	KLF12
15	63.733–65.208	15q22	5.9 × 10−13	FAM96A
20	30.578–31.091	20q11	2.5 × 10−7	CCM2L

Note.—Genetic loci with genome-wide significant natural selection signatures are shown (P_ASMC < 0.05/71,320 bins = 7.0 × 10⁻⁷). A gene nearest to the top bin of each region is indicated.