Table 1. Top 20 up- and down-regulated genes in Cyp1b1-/-AC.
| Symbol | Description | Log2FC | p-value | FDR |
|---|---|---|---|---|
| Up-regulated | ||||
| Eif2s3y | eukaryotic translation initiation factor 2, subunit 3, structural gene Y-linked | 12.01499 | 0 | 0 |
| Uty | ubiquitously transcribed tetratricopeptide repeat gene, Y chromosome | 11.91885 | 3.6E-164 | 1.9E-161 |
| Ddx3y | DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked | 11.79096 | 0 | 0 |
| Kdm5d | lysine (K)-specific demethylase 5D | 10.28087 | 8.9E-151 | 4E-148 |
| Gm43302 | predicted gene 43302 | 9.580986 | 1.21E-12 | 2E-11 |
| Rpl15-ps2 | ribosomal protein L15, pseudogene 2 | 9.550535 | 2.2E-235 | 3.8E-232 |
| Bmp8b | bone morphogenetic protein 8b | 8.847732 | 0 | 0 |
| Cysltr1 | cysteinyl leukotriene receptor 1 | 8.342675 | 1.93E-30 | 1.16E-28 |
| Gm26760 | predicted gene, 26760 | 8.102196 | 5.58E-28 | 2.97E-26 |
| Gm10020 | predicted pseudogene 10020 | 7.874941 | 1.6E-233 | 2.5E-230 |
| Gm6969 | predicted pseudogene 6969 | 6.85453 | 7.82E-74 | 1.63E-71 |
| Dsp | desmoplakin | 6.813457 | 9.78E-10 | 1.13E-08 |
| Actg-ps1 | actin, gamma, pseudogene 1 | 6.722348 | 1.08E-11 | 1.58E-10 |
| Sgsm1 | small G protein signaling modulator 1 | 6.689262 | 1.12E-59 | 1.78E-57 |
| Cdx2 | caudal type homeobox 2 | 6.474141 | 2.61E-26 | 1.27E-24 |
| Gm38312 | predicted gene, 38312 | 6.410902 | 1.62E-77 | 3.66E-75 |
| Oxct2b | 3-oxoacid CoA transferase 2B | 6.374568 | 4.13E-23 | 1.59E-21 |
| AI593442 | expressed sequence AI593442 | 6.040882 | 1.6E-116 | 6E-114 |
| Gm45315 | predicted gene 45315 | 6.018783 | 7.76E-65 | 1.3E-62 |
| Adarb2 | adenosine deaminase, RNA-specific, B2 | 5.88212 | 2.23E-18 | 6.17E-17 |
| Down-regulated | ||||
| Ptprf | protein tyrosine phosphatase, receptor type, F | -1.009044 | 3.978E-53 | 5.686E-51 |
| Gprc5a | G protein-coupled receptor, family C, group 5, member A | -1.02267 | 2.718E-12 | 4.306E-11 |
| Vax2 | ventral anterior homeobox 2 | -1.025959 | 5.515E-10 | 6.507E-09 |
| Fgf10 | fibroblast growth factor 10 | -1.028563 | 3.695E-21 | 1.264E-19 |
| Stard9 | START domain containing 9 | -1.030828 | 2.45E-13 | 4.349E-12 |
| Lmo1 | LIM domain only 1 | -1.031322 | 5.887E-17 | 1.438E-15 |
| Prl2c3 | prolactin family 2, subfamily c, member 3 | -1.034173 | 1.076E-22 | 4.025E-21 |
| Gm27177 | predicted gene 27177 | -1.034225 | 3.073E-17 | 7.67E-16 |
| Tgfb3 | transforming growth factor, beta 3 | -1.035388 | 2.308E-12 | 3.687E-11 |
| Flrt3 | fibronectin leucine rich transmembrane protein 3 | -1.038403 | 8.71E-09 | 8.981E-08 |
| Acsf2 | acyl-CoA synthetase family member 2 | -1.040813 | 9.692E-12 | 1.426E-10 |
| Ppic | peptidylprolyl isomerase C | -1.042228 | 5.977E-32 | 3.847E-30 |
| Eif3j1 | eukaryotic translation initiation factor 3, subunit J1 | -1.042647 | 4.709E-42 | 5.158E-40 |
| Mical1 | microtubule associated monooxygenase, calponin and LIM domain containing 1 | -1.046611 | 1.687E-09 | 1.899E-08 |
| Ndrg2 | N-myc downstream regulated gene 2 | -1.047743 | 2.791E-13 | 4.941E-12 |
| Ptgs1 | prostaglandin-endoperoxide synthase 1 | -1.0487 | 5.856E-29 | 3.273E-27 |
| Cbr3 | carbonyl reductase 3 | -1.050294 | 2.114E-16 | 4.933E-15 |
| Slfn8 | schlafen 8 | -1.061261 | 4.262E-23 | 1.64E-21 |
| Aplp1 | amyloid beta (A4) precursor-like protein 1 | -1.075804 | 8.932E-14 | 1.662E-12 |
| Steap3 | STEAP family member 3 | -1.08044 | 5.467E-14 | 1.046E-12 |
The cutoff criteria for this list was any DEG with a FC> 5.88 for upregulation and FC> -1.009 for downregulation.