Figure 5.

Forest plot depicting risk predictors for developing incident hypertrophic cardiomyopathy with left ventricular systolic dysfunction (HCM-LVSD). Unadjusted number of events per variable is shown in second column. Cox proportional hazards model is based on 2816 patients, of whom170 developed incident HCM-LVSD. Hazard ratios are adjusted for all included risk factors. The diamond symbol in the cohort with ≥1 pathogenic/likely pathogenic variant (SARC+) represents the composite effect of thin filament, thick filament, and multiple pathogenic/likely pathogenic (P/LP) sarcomeric variants. LVEF indicates left ventricular ejection fraction; LVIDd, left ventricular diastolic diameter; ref, referent; SARC−, no clinically relevant sarcomere variants identified on genetic testing; SARC VUS, a variant of unknown significance in a sarcomere gene; and SRT, septal reduction therapy.