Table 4. Power comparison of TQ, DOT, and ACAT with effect sizes randomly sampled from -0.15 to 0.15 and heterogeneous LD.
Number of SNPs | Empiric. | Theor. | P-approx. | Empiric. | Theor. | ACAT | |
---|---|---|---|---|---|---|---|
L | TQ | TQ | TQ | DOT | DOT | ||
500 | 0.0500 | 0.0503 | 0.0508 | 0.9226 | 0.9222 | 0.0564 | 0.2118 |
300 | 0.0506 | 0.0503 | 0.0509 | 0.7688 | 0.7689 | 0.0570 | 0.2107 |
200 | 0.0504 | 0.0503 | 0.0508 | 0.5970 | 0.5967 | 0.0570 | 0.2025 |
100 | 0.0504 | 0.0503 | 0.0509 | 0.3040 | 0.3038 | 0.0568 | 0.1655 |
50 | 0.0502 | 0.0503 | 0.0508 | 0.3074 | 0.3070 | 0.0555 | 0.2397 |
30 | 0.0505 | 0.0503 | 0.0507 | 0.1485 | 0.1487 | 0.0562 | 0.1527 |
20 | 0.0501 | 0.0503 | 0.0508 | 0.1191 | 0.1189 | 0.0557 | 0.1399 |