. Author manuscript; available in PMC: 2021 Mar 18.

Published in final edited form as: Neuron. 2020 Jan 23;105(6):1027–1035.e2. doi: 10.1016/j.neuron.2019.12.031

Table 1. Disease demographics and repositories analyzed.

Two data types were analyzed from three different brain banks: (1) RNAseq data from AD and non-AD control brains were analyzed via PathSeq from both MSBB (n=301) and ROSMAP (n=600) cohorts, while (2) DNA extracted from AD and non-AD control brains from both ROSMAP (n=364) and JHBRC (n=344) was assessed for PCR reactivity.

Mount Sinai Brain Bank (MSBB)		Religious Orders Study/Memory and Aging Project (ROSMAP)				Johns Hopkins Brain Resource Center (JHBRC)
RNAseq		RNAseq		DNA ddPCR		DNA ddPCR
n=301^a		n=600		n=364		n=344
Definite AD^b	135	Definite AD^b	173	AD	267	AD	243
Definite AD^b	135	Definite AD^b	173			Multiple System Atrophy (MSA)	12
Probable AD^b	42	Probable AD^b	207			Multiple System Atrophy (MSA)	12
Possible AD ^b	38	Possible AD^b	62	Non-AD controls	97	Progressive Supranuclear Palsy (PSP)	20
Non-AD controls^b	86	Non-AD controls^b	158			Progressive Supranuclear Palsy (PSP)	20
Non-AD controls^b	86	Non-AD controls^b	158			Non-AD controls	69

Up to 4 brain regions screened per individual (BM10, BM22, BM36, BM44). Total # specimens=1027

AD classification coding: Neuropathology categories as measured by CERAD (Wang et al., 2018; Bennett et al., 2012a; Bennett et al., 2012b)