Table 2.
HE/EO Effects on TNF-α Level and Oxidative Stress Biomarkers in the Serum of Diabetic Mice
| Groups | TNF-α (ng/L) | TAC (µmol/mL) | LPO (nmol/mL) |
|---|---|---|---|
| Control | 5.8±1.1 | 1.4±0.15 | 1.8±0.36 |
| STZ | 8.1±0.91aa | 0.8±0.07aa | 2.1±0.49aaa |
| HE (200 mg/kg) | 6.1±0.82 | 1.25±0.17 | 4.9±0.94 |
| STZ+HE (50 mg/kg) | 6.8±0.49 | 0.94±0.08 | 4.4±0.50 |
| STZ+HE (100 mg/kg) | 7.2±0.65 | 1.07±0.05 | 3.8±0.36b |
| STZ+HE (200 mg/kg) | 6.2±0.37b | 1.3±0.13bb | 2.9±0.31bbb |
| EO (200 mg/kg) | 6.4±1.2 | 1.3±0.08 | 2.5±0.53 |
| STZ+EO (50 mg/kg) | 7.8±0.97 | 0.9±0.21 | 3.1±0.94 |
| STZ+EO (100 mg/kg) | 7.4±0.38 | 1.1±0.25 | 2.9±0.54 |
| STZ+EO (200 mg/kg) | 6.9±0.41 | 1.2±0.09 | 3.6±0.63 |
Notes: Analysis used one-way ANOVA with Tukey’s test. Values are expressed as means±SEM, n=6 for each group. Significantly different from the control group; aaP<0.01 and aaaP<0.001. Significantly different from the diabetic group bP<0.05, bbP<0.01, and bbbP<0.001.
Abbreviations: HE, hydroalcoholic extract; EO, essential oil; STZ, streptozotocin; TNF-α, tumor necrosis factor-α; TAC, total antioxidant capacity; LPO, lipid peroxidation.