Table 3.

Relationship Between TNFAIPs and Malignant Tumors

TNFAIPs	Related Tumors	Function	Clinical Significance		References
			Prediction	Prognostic
TNFAIP1	Gastric cancer	Regulate proliferation and apoptosis	No	No	[10–14,56]
	Osteosarcoma	Inhibit proliferation and induce apoptosis	Yes	No
	NSCLC	Participate in proliferation and invasion	Yes	No
	Pancreatic cancer	Regulate proliferation and metastasis	Yes	No
TNFAIP2	NPC ESCC Gastric cancer SCCHN Breast cancer	Promote proliferation, invasion and metastasis Interfere with miRNA mediated gene regulation Regulate expression by functional SNP Regulate expression by functional SNP Promote proliferation, invasion and metastasis	Yes Yes Yes Yes No	Yes No No No No	[15,16,59–61]
TNFAIP3	Lymphoma	Negative regulate NF-κB signaling pathway	No	No	[25,27]
	Multiple myeloma	Negative regulate NF-κB signaling pathway	No	No
TNFAIP4	Gastric cancer	Regulate tumor formation and susceptibility	Yes	Yes	[63–67]
	CRC	Participate in tumor-related angiogenesis	Yes	No
TNFAIP5	Lung cancer	Auxiliary differential diagnosis	Yes	Yes	[68–71]
	CRC	Promote proliferation, invasion and metastasis	No	Yes
	Hepatic carcinoma	Promote proliferation, invasion and metastasis	Yes	Yes
TNFAIP8	NSCLC Pancreatic cancer Prostate cancer Cervical cancer Endometrial cancer Gastric cancer Breast cancer Colorectal cancer	Promote proliferation, invasion, metastasis and cisplatin chemoresistance Strongly stained in pancreatic cancer tissues Promote proliferation, invasion and metastasis Regulate the affinity between miR-22 and 3ʹUTR domain Promote proliferation and metastasis Regulate proliferation, apoptosis, invasion and metastasis Promote metastasis by regulating VEGFR2, MMP-1 and MMP-9 Promote angiogenesis by regulating VEGFR2 expression	Yes No Yes No Yes Yes Yes Yes	Yes No Yes No No Yes Yes No	[43,45,48,49,72–76,81,82]
TNFAIP9	Prostate cancer	Inhibit proliferation, clone formation and adherent growth	No	No	[52]

Abbreviations: TNFAIP, tumor necrosis factor alpha-induced protein; NSCLC, non-small cell lung cancer; NPC, nasopharyngeal carcinoma; ESCC, esophageal squamous cell carcinoma; miRNA, micro ribonucleic acid; SNP, single nucleotide polymorphism; SCCHN, head and neck squamous cell carcinoma; NF-κB, nuclear factor kappa B; CRC, colorectal cancer; 3ʹUTR, 3ʹuntranslated region; VEGFR2, vascular endothelial growth factor receptor 2; MMP, matrix metalloproteinases.