Table 1.
Summary of the Predictive Value of MetS on CVD Morbidity
| Study | Participants (n) | Age (Years) | Follow-Up (Years) | Definition of MetS (Abdominal Obesity) | CVD Incidence | Coronary Heart Disease | Stroke | |||
|---|---|---|---|---|---|---|---|---|---|---|
| n | HR (95% CI) | n | HR (95% CI) | n | HR (95% CI) | |||||
| Suita Studya [Kokubo Y, et al]16 | M: 2492 | 30–79 | 12.5 | Japanese | M: 48 | 1.34 (0.96–1.87) | M: 22 | 1.51 (0.91–2.48) | M: 26 | 1.27 (0.81–1.97) |
| W: 2840 | (Waist circumference) | W: 19 | 2.20 (1.31–3.68) | W: 7 | 2.70 (1.15–6.35) | W: 12 | 2.05 (1.07–3.92) | |||
| NCEP-ATPIII (Asian) | M: 55 | 1.75 (1.27–2.41) | M: 26 | 2.12 (1.31–3.43) | M: 29 | 1.58 (1.02–2.43) | ||||
| (Waist circumference) | W: 56 | 1.90 (1.31–2.77) | W: 21 | 2.77 (1.44–5.32) | W: 35 | 1.62 (1.02–2.58) | ||||
| Hisayama Studyb [Doi Y, et al]17 | M: 1050 | ≥40 | 14 | Japanese | M: 34 | 1.28 (0.86–1.91) | – | – | – | – |
| W: 1402 | (Waist circumference) | W: 19 | 1.89 (1.15–3.10) | – | – | – | – | |||
| Modified Japanese | M: 24 | 2.49 (1.57–3.94) | – | – | – | – | ||||
| (Waist circumference) | W: 47 | 2.27 (1.55–3.32) | – | – | – | – | ||||
| Modified NCEP-ATPIII | M: 40 | 1.66 (1.14–2.43) | – | – | – | – | ||||
| (Waist circumference) | W: 62 | 1.88 (1.30–2.74) | – | – | – | – | ||||
Notes: aAdjusted Confounders: age, smoking, drinking. bAdjusted Confounders: age, proteinuria, cholesterol, electrocardiogram abnormalities, alcohol, exercise, smoking. The bold text shows a HR (95% CI) level with a significance of P<0.05.
Abbreviations: MetS, metabolic syndrome; CVD, cardiovascular disease; n, number; M, men; W, women; HR, hazard ratio; CI, confidence interval, NCEP-ATPIII, National Cholesterol Education Program - the third revision of Adult Treatment Panel.