Figure 5: DT-induced antral aganglionosis causes delayed gastric emptying.
Gastric emptying was quantitatively assessed in control (a) and Wnt1-iDTR (b) mice 4 weeks after DT injection. No significant difference in survival was observed (c). Both liquid (d) and solid (e) emptying in Wnt1-iDTR mice were delayed at 2 weeks following DT injection (d, e, Control (n=6) vs Wnt1-iDTR (n=7), p<0.05). These changes persisted at 4 weeks following DT injection (d, e, Control (n=6) vs Wnt1-iDTR (n=4), p<0.05).