Table 1.

Comparison of baseline characteristics between nonproliferative diabetic retinopathy patients who did not progress and those who did progress to vision threatening diabetic retinopathy (VTDR)

	No progression to VTDR (N = 57,212)	Progressed to VTDR (N = 12,770)
Age (Mean (SD))	61.7 (12.9)	60.5 (12.1)
Gender
Female	26,617 (46.5%)	6,271 (49.1%)
Male	30,595 (53.5%)	6499 (50.9%)
Race
White	31,066 (54.3%)	7266 (56.9%)
Black	8944 (15.6%)	2334 (18.3%)
Asian	2835 (5.0%)	445 (3.5%)
Hispanic	9004 (15.7%)	1837 (14.4%)
Unknown	5363 (9.4%)	888 (7.0%)
Hypertension	47,999 (83.9%)	10,952 (85.8%)
Hypercholesterolemia	48,739 (85.2%)	11,003 (86.2%)
Previous ischemic stroke/TIA	4729 (8.3%)	1111 (8.7%)
Previous intracerebral hemorrhage	323 (0.6%)	39 (0.3%)
Chronic liver disease	464 (0.8%)	95 (0.7%)
Peripheral vascular disease	10,734 (18.8%)	2523 (19.8%)
Any malignancy	5868 (10.3%)	1315 (10.3%)
eGFR (kidney function)
Normal (≥90)	11127 (19.4%)	2254 (17.7%)
Mild (60–89)	22850 (39.9%)	4861 (38.1%)
Moderate (45–59)	7471 (13.1%)	1648 (12.9%)
Mod/severe (30–44)	3771 (6.6%)	912 (7.1%)
Severe (15–29)	1270 (2.2%)	334 (2.6%)
End stage disease or dialysis (<15)	4803 (8.4%)	1478 (11.6%)
Unknown	5920 (10.3%)	1283 (10.0%)
Hemoglobin A1c (Mean (SD))	7.1 (2.9)	7.1 (3.3)
Insulin Use	11529 (20.2%)	2824 (22.1%)
Diabetes Comp Sev Index
1	17736 (31.0%)	3567 (27.9%)
2–3	18168 (31.8%)	4111 (32.2%)
4	6330 (11.1%)	1586 (12.4%)
5–12	14978 (26.2%)	3506 (27.5%)
Anaemia
Normal (M ≥ 13.0, W ≥ 12.0)	24,090 (42.1%)	4916 (38.5%)
Mild (M:11.0–12.9, W:11.0–11.9)	5829 (10.2%)	1362 (10.7%)
Mod/severe (≤10.9)	2684 (4.7%)	637 (5.0%)
Unknown	24,609 (43.0%)	5855 (45.8%)
Chronic pulmonary disease	12,656 (22.1%)	3003 (23.5%)
History of blood disorder/cancer	1160 (2.0%)	290 (2.3%)