Table 3.
Signature amino acids characterizing genotypes/subgenotypes/lineages for RSV‐A (A) and B (B)
| (A) | |
|---|---|
| RSV‐A genotypes | Signature amino acids |
| GA1 | 101P,104P,111I,121G,123K,141A,157S,244I/T,258L,262M,280S,293P |
| GA2 | I111P/S/F, P226L/H |
| GA2.1 | K229N/S |
| GA2.2 | V122A,[I114T + L115P+S117P/L] |
| GA2.3 | V122A, P156Q,P289S/Y/F,S269T |
| GA2.3.1 | as GA2.3 plus T252I,G254E |
| GA2.3.2 | as GA2.3 plus T133I |
| GA2.3.2a | as GA2.3.2 plus N242S,V225I |
| GA2.3.2b | as GA2.3.2 plus T112I,I141M,R244K/N |
| GA2.3.3 | as GA2.3 plus P111S, P292S/L |
| GA2.3.4 | as GA2.3 plus F208L, N273Y/H |
| GA2.3.5 | as GA2.3 plus insertion 261‐284 ,E232G/R,T253K/R |
| GA2.3.6a | as GA2.3.5 plus [V225A + L274P * ] |
| GA2.3.6b | as GA2.3.5 plus [P206Q + L274P/S * ] |
| GA3 | I111T, S250N |
| GA3.0.0 | I111T, S250N |
| GA3.0.1 | S102F,N191S, T295I |
| GA3.0.2 | as above plus T113A,T125I, P274T |
| GA3.0.3 | as above plus N161D,N297D |
| GA3.0.3a | as GA3.0.3 plus E232D |
| GA3.0.4a | as GA3.0.3a plus T227S |
| GA3.0.3b | as GA3.0.3 |
| GA3.0.4b | as GA3.0.3b plus S217P,S224P,P246L,P206Q |
| GA3.0.5b | as GA3.0.4b plus N153K. |
| (B) | |
|---|---|
| RSV‐B genotypes | Signature amino acids |
| GB1 | 137I,150S,152 S ,208I,222 M ,271S,280I |
| GB2 | I118T, P223T ,S257L |
| GB3 | R136I |
| GB4 | P216S, P219S,M222A, K224R, N230D,K234E,Q248R,K258D |
| GB5 | T143N,L237P/S |
| GB5.0.0 | T143N,L237P/S |
| GB5.0.1 | as above, plus insertion 245‐264,S247P * |
| GB5.0.2 | as above, plus T138S/F , K158‐P159del a ,L223P |
| GB5.0.3 | as above, plus V271A |
| GB5.0.4a | as GB5.0.3 plus [ I200T + I281T ] |
| GB5.0.5a | as GB5.0.4a plus R136T,T254I * |
| GB5.0.4b | as GB5.0.3 plus [ S267L + S297F/L ] and K153R or I111T |
| GB5.0.4c | as GB5.0.3 plus S291L or E305D |
| GB5.0.5c | as GB5.0.4c subclade S291L,plus R262G * |
| GB6 | A116T, T126K, P235L, Q262L/P |
| GB7 | Q180R ,R214I,T239I, R242K,V251M/I, E272D |
Amino acid annotation follows the format “X122Y,” where X = reference, Y = signature, number = position from beginning of G‐ORF. Signature amino acids are defined against the consensus sequence of GA1 for RSV‐A and GB1 for RSV‐B. “Main” amino acid signatures are in bold, “secondary” changes are in italics. Substitutions in square brackets are needed in combination to be considered as signature amino acids.
alternative position for this deletion: P159‐K160del.
Substitutions located within the duplication region of the G gene (72nt in RSV‐A or 60nt in RSV‐B). For these substitutions, the positions were described using strains JN257693_CAN_2010 (RSV‐A) and DQ227364_ARG_1999 (RSV‐B) as reference sequences.