Table 2.

Thrombophilia: risk factors graded as major, minor, persistent, transient

Major persistent	Major transient
Male sex	Surgery
Age > 65 years	Trauma
Active cancer	Cesarean section
Myeloproliferative neoplasm	Pregnancy—Puerperium
Antiphospholipid syndrome	Severe infection
Behçet disease—Hughes–Stovin syndrome	Nephrotic syndrome
Cushing syndrome
Paroxysmal nocturnal hemoglobinuria (PNH)
Klinefelter syndrome
Sickle cell disease
Some forms of inherited thrombophilia

Minor persistent	Minor transient
Some forms of inherited thrombophilia	Smoking
Non-O blood group	Dehydration
BMI > 30 kg/m2	Treatment with synthetic estrogens
Post thrombotic syndrome	Varicosis
Chronic bowel inflammatory disease	Immobilisation—Flight > 4 h
Lower extremity paralysis or paresis	Intermittent chemotherapy
Congestive heart failure	Testosterone therapy
Depression
Lupus anticoagulants
Calculated creatinine clearance < 50 mL per minutes

Adapted from [49]